Abstract | BACKGROUND: METHODS: We decided to verify the impact of the FGFR4 Arg(388) allele on survival as well as its association with histoclinical data in 75 cases of HNSCC. The FGFR4 Arg(388) allele was detected by PCR-RFLP and DNA sequencing. RESULTS: The FGFR4 Arg(388) allele was detected in 42.5% of the tumors (37% heterozygous Gly/Arg and 5.5% homozygous Arg/Arg). The presence of at least one Arg allele was significantly correlated with reduced overall survival after 24 months of follow-up. The cases involving the Arg allele presented an increased mortality risk of 2.2 if compared to the non-carrier cases. CONCLUSION: The FGFR4 Arg(388) allele is associated with a shortened survival.
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Authors | Valéria Cristina da Costa Andrade, Orlando Parise Jr, Cora Pereira Hors, Poliana Cristina de Melo Martins, Alexandre Pacheco Silva, Bernardo Garicochea |
Journal | Experimental and molecular pathology
(Exp Mol Pathol)
Vol. 82
Issue 1
Pg. 53-7
(Feb 2007)
ISSN: 0014-4800 [Print] Netherlands |
PMID | 17084840
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- FGFR4 protein, human
- Receptor, Fibroblast Growth Factor, Type 4
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Topics |
- Alleles
- Carcinoma, Squamous Cell
(genetics, mortality, pathology)
- Female
- Head and Neck Neoplasms
(genetics, mortality, pathology)
- Humans
- Male
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Polymorphism, Single Nucleotide
- Prognosis
- Receptor, Fibroblast Growth Factor, Type 4
(genetics)
- Survival Analysis
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