[A prospective control study on treatment of stress urinary incontinence with alpha-adrenoceptor agonists and pelvic floor muscle exercises].

Abstract

OBJECTIVE:

To evaluate the therapeutic results of alpha-adrenoceptor agonists and pelvic floor muscle exercises (PFME) for stress urinary incontinence.

METHODS:

A prospective, single-center, random control study was carried out in 46 patients with stress urinary incontinence (SUI). The patients were divided into two groups, 22 in alpha-adrenoceptor agonists group vs 24 in PFME group. Clinical outcomes and the scores of quality of life were evaluated and compared between the two groups.

RESULTS:

Two patients in alpha-adrenoceptor agonists group and four patients in PFME group were failed to complete the study. According to patient's subjective scores, excellent effective rate was 15% (3/20) and effective rate was 85% (17/20) in alpha-adrenoceptor agonists group versus effective rate of 55% (11/20) and no-effective rate of 45% (9/20) in PFME group. According to objective 1 h pad test criteria, the efficacy was significantly better in alpha-adrenoceptor agonists group (P < 0.01). The scores of quality of life were improved in all patients of two groups after treatment, and were significantly better in alpha-adrenoceptor agonists group (P < 0.05). There was no difference in sexual life score in PFME group and alpha-adrenoceptor agonists group.

CONCLUSIONS:

Both alpha-adrenoceptor agonists and PFME are effective non-surgical treatments for stress urinary incontinence. However, alpha-adrenoceptor agonists have better effect than PFME.

• Authors: Lan Zhu, Jing-he Lang, Ning Hai, Yan Li, He Xiao
• Journal: Zhonghua fu chan ke za zhi (Zhonghua Fu Chan Ke Za Zhi) Vol. 41 Issue 8 Pg. 537-9 (Aug 2006) ISSN: 0529-567X [Print] China
• PMID: 17083839 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Adrenergic alpha-Agonists

Topics

• Adrenergic alpha-Agonists (pharmacology, therapeutic use)
• Adult
• Exercise Therapy (methods)
• Female
• Humans
• Middle Aged
• Pelvic Floor (physiology)
• Prospective Studies
• Quality of Life
• Surveys and Questionnaires
• Treatment Outcome
• Urinary Incontinence, Stress (drug therapy, physiopathology, therapy)