Abstract | BACKGROUND AND PURPOSE: METHODS: Intima-media thickness of the common carotid artery, as well as incident stroke and myocardial infarction, were studied within 6471 subjects of the Rotterdam Study. Within 1018 subjects of the Rotterdam Scan Study, prevalent silent brain infarcts and cerebral white matter lesions were studied. Subjects were grouped into 460Trp carriers (variant carriers) and homozygous carriers of the Gly460 allele (reference). RESULTS: Intima-media thickness of the common carotid artery was 0.80 mm in variant carriers compared with 0.79 mm in the reference group (P=0.04). Variant carriers had an increased risk of any stroke (hazard ratio [HR], 1.22; 95% CI, 1.02 to 1.45), ischemic stroke (HR, 1.29; 95% CI, 1.02 to 1.63), hemorrhagic stroke (HR, 1.07; 95% CI, 0.59 to 1.92), and of myocardial infarction (HR, 1.33; 95% CI, 1.05 to 1.69). For any ischemic stroke, there was a significant interaction between the Gly460Trp polymorphism and hypertension. Variant carriers more often had a silent brain infarct (odds ratio, 1.36; 95% CI, 0.98 to 1.88) and had more subcortical white matter lesions than the reference group (1.45 vs1.24 mL; P=0.22). CONCLUSIONS:
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Authors | Marie Josee E van Rijn, Michiel J Bos, Mojgan Yazdanpanah, Aaron Isaacs, Alejandro Arias-Vásquez, Peter J Koudstaal, Albert Hofman, Jacqueline C Witteman, Cornelia M van Duijn, Monique M B Breteler |
Journal | Stroke
(Stroke)
Vol. 37
Issue 12
Pg. 2930-4
(Dec 2006)
ISSN: 1524-4628 [Electronic] United States |
PMID | 17082469
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Calmodulin-Binding Proteins
- adducin
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Topics |
- Aged
- Atherosclerosis
(epidemiology, genetics)
- Calmodulin-Binding Proteins
(genetics)
- Cardiovascular Diseases
(epidemiology, genetics)
- Carotid Artery Diseases
(epidemiology, genetics)
- Cerebrovascular Disorders
(epidemiology, genetics)
- Cohort Studies
- Female
- Humans
- Male
- Middle Aged
- Myocardial Infarction
(epidemiology, genetics)
- Netherlands
(epidemiology)
- Polymorphism, Genetic
- Prospective Studies
- Risk Factors
- Stroke
(epidemiology, genetics)
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