Efficacy of the Kampo medicine Xiong-gui-jiao-ai-tang, a traditional herbal medicine, in the treatment of threatened abortion in early pregnancy.

This study was carried out to evaluate the clinical efficacy of Xiong-gui-jiao-ai-tang (Kyuki-kyogai-to), a traditional Chinese herbal medicine, in the treatment of threatened abortion in early pregnancy. We enrolled 72 women diagnosed with threatened abortion at Osaka Medical College Hospital and assigned them at random to the following two groups: a group of 36 women who received Xiong-gui-jiao-ai-tang at a dose of 7.5 g/day and another group of 36 women who received human chorionic gonadotropin (hCG)(control group). We found that in the Xiong-gui-jiao-ai-tang group (2.9 + or - 3.5 days), the number of days required before hemostasis was reached in the uterus was significantly shorter than in the control group (10.8 + or - 8.2 days, p < 0.0001). Furthermore, the number of days required for retroplacental hematoma in the vicinity of the gestational sac to disappear was significantly shorter in the Xiong-gui-jiao-ai-tang group (9.9 + or - 7.1 days) than in the control group (23.2 + or - 12.8 days) (p < 0.0001). In retroplacental hematoma size, significant rates of reduction were obtained in both major and minor axis measurements at the 7th day of treatment for the Xiong-gui-jiao-ai-tang group compared to the control group (control vs Xiong-gui-jiao-ai-tang: major axis: 7.5 + or - 3.8% vs 42.3 + or - 10.5%; minor axis: 15.3 + or - 16.8% vs 71.5 + or - 48.2%)(p < 0.0001, each case). The results of this study demonstrated the beneficial effects of Xiong-gui-jiao-ai-tang in stabilizing early pregnancy. Xiong-gui-jiao-ai-tang can be expected to improve unstable early pregnancy with uterine bleeding and to prevent abortion.
AuthorsTakahisa Ushiroyama, Ryoji Araki, Kou Sakuma, Sakura Nosaka, Yoshiki Yamashita, Hideki Kamegai
JournalThe American journal of Chinese medicine (Am J Chin Med) Vol. 34 Issue 5 Pg. 731-40 ( 2006) ISSN: 0192-415X [Print] Singapore
PMID17080540 (Publication Type: Journal Article, Randomized Controlled Trial)
Chemical References
  • Drugs, Chinese Herbal
  • xiong-gui-jiao-ai-tang
  • Abortion, Threatened (drug therapy)
  • Adult
  • Drugs, Chinese Herbal (therapeutic use)
  • Female
  • Hematoma (drug therapy, pathology)
  • Hemostasis (drug effects)
  • Humans
  • Phytotherapy
  • Placenta Diseases (drug therapy, pathology)
  • Pregnancy
  • Pregnancy Complications (drug therapy, pathology)
  • Time Factors
  • Treatment Outcome
  • Young Adult

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