Smoking-responsive juvenile-onset Parkinsonism.

Abstract

We describe a patient with juvenile levodopa-responsive Parkinsonism who reported a dramatic response to cigarette smoking with transient but marked improvement of motor symptoms associated with oculogyric crises and psychotic behavior. His beta-CIT single-photon emission computed tomography scan showed a complete absence of presynaptic dopaminergic nerve terminals.

• Authors: Hasmet Ayhan Hanagasi, Andrew Lees, Janel O Johnson, Andrew Singleton, Murat Emre
• Journal: Movement disorders : official journal of the Movement Disorder Society (Mov Disord) Vol. 22 Issue 1 Pg. 115-9 (Jan 2007) ISSN: 0885-3185 [Print] United States
• PMID: 17080433 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright 2006 Movement Disorder Society.

Chemical References

• Nicotinic Agonists
• Tropanes
• 2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane
• Nicotine

Topics

• Adult
• Humans
• Male
• Nicotine (therapeutic use)
• Nicotinic Agonists (therapeutic use)
• Parkinsonian Disorders (diagnostic imaging, drug therapy)
• Smoking
• Tomography, Emission-Computed, Single-Photon
• Tropanes (pharmacokinetics)