Synthesis of estradiol-pheophorbide a conjugates: evidence of nuclear targeting, DNA damage and improved photodynamic activity in human breast cancer and vascular endothelial cells.

Abstract	The synthesis, physico-chemical properties, cellular localization and photocytotoxicity of estradiol-pheophorbide a conjugates in estrogen-dependent cancer and vascular endothelial cells are described with the aim of increasing the photodynamic activity by targeting the nucleus of both tumor and blood vessel cells.
Authors	Naram El-Akra, Arielle Noirot, Jean-Charles Faye, Jean-Pierre Souchard
Journal	Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology (Photochem Photobiol Sci) Vol. 5 Issue 11 Pg. 996-9 (Nov 2006) ISSN: 1474-905X [Print] England
PMID	17077894 (Publication Type: Journal Article)
Chemical References	Reactive Oxygen Species Chlorophyll Estradiol pheophorbide a
Topics	Breast Neoplasms (drug therapy, pathology) Cell Line, Tumor Chlorophyll (analogs & derivatives, chemical synthesis, chemistry, pharmacology) DNA Damage Endothelium, Vascular (cytology, drug effects) Estradiol (chemical synthesis, chemistry, pharmacology) Humans Photochemotherapy Reactive Oxygen Species Spectrometry, Fluorescence Spectrum Analysis (methods)

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