Semisynthesis of isetexane diterpenoid analogues and their cytotoxic activity.

Abstract

Isetexane diterpene analogues were semisynthesized from demethylsalvicanol isolated from Perovskia abrotanoides (Labiatae). The structure and cytotoxic activity relationships (SAR) of the natural parent diterpene, demethylsalvicanol, and its semisynthetic analogues were studied by using P388 murine leukemia cells.

• Authors: Yutaka Aoyagi, Yoshinao Takahashi, Haruhiko Fukaya, Koichi Takeya, Ritsuo Aiyama, Takeshi Matsuzaki, Shusuke Hashimoto, Teruo Kurihara
• Journal: Chemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 54 Issue 11 Pg. 1602-4 (Nov 2006) ISSN: 0009-2363 [Print] Japan
• PMID: 17077562 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Diterpenes
• demethylsalvicanol

Topics

• Animals
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Diterpenes (chemical synthesis, chemistry, pharmacology)
• Dose-Response Relationship, Drug
• Drug Screening Assays, Antitumor
• Lamiaceae (chemistry)
• Leukemia P388 (drug therapy)
• Mice
• Molecular Conformation
• Stereoisomerism
• Structure-Activity Relationship
• Tumor Cells, Cultured