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Dykellic acid inhibits cell migration and tube formation by RhoA-GTP expression.

Abstract
Dykellic acid, a novel factor initially identified from the culture broth of Westerdykella multispora F50733, has been shown to inhibit matrix metalloprotease 9 activity, caspase-3 activity, B cell proliferation and LPS-induced IgM production, suggesting that this factor may have anti-cancer effects. In an effort to further address the possible anti-tumoral effects of dykellic acid, we used wound healing, invasion and RhoA-GTP assays to examine the effects of dykellic acid on cell migration, invasion and angiogenesis. Our results revealed that dykellic acid dose-dependently inhibits B16 cell migration and motility, and inhibits HUVEC tube formation. Western blot analysis of the active form of RhoA (RhoA-GTP) showed that dykellic acid treatment decreased the levels of RhoA-GTP. These findings collectively suggest that dykellic acid may have both anti-metastatic and anti-angiogenic acitivites, and provides the first evidence for the involvement of RhoA in dykellic acid-induced effects.
AuthorsJin-Chul Heo, Ja-Young Park, Sang-Uk Woo, Jae-Rang Rho, Ho-Jae Lee, Sung-Uk Kim, Yung-Hee Kho, Sang-Han Lee
JournalBiological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 29 Issue 11 Pg. 2256-9 (Nov 2006) ISSN: 0918-6158 [Print] Japan
PMID17077524 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Propionates
  • Pyrones
  • dykellic acid
  • rhoA GTP-Binding Protein
Topics
  • Animals
  • Blood Vessels (drug effects, physiology)
  • Blotting, Western
  • Cell Line
  • Cell Line, Tumor
  • Cell Movement (drug effects)
  • Cell Proliferation (drug effects)
  • Dose-Response Relationship, Drug
  • Endothelial Cells (drug effects, physiology)
  • Humans
  • Mice
  • Neoplasm Invasiveness (prevention & control)
  • Neovascularization, Pathologic (metabolism, prevention & control)
  • Propionates (chemistry, pharmacology)
  • Pyrones (chemistry, pharmacology)
  • rhoA GTP-Binding Protein (metabolism)

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