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Staphylococcal enterotoxin B in vivo modulates both gamma interferon receptor expression and ligand-induced activation of signal transducer and activator of transcription 1 in T cells.

Abstract
Superantigens (SAg) are bacterial exotoxins that provoke extreme responses in the immune system; for example, the acute hyperactivation of SAg-reactive T cells that leads to toxic shock syndrome is followed within days by strong immunosuppression. The gamma interferon (IFN-gamma) response is deeply affected in both extremes. The implication of IFN-gamma in the pathophysiology of lethal shock induced in mice after a secondary challenge with the SAg staphylococcal enterotoxin B (SEB) prompted us to study the regulation of IFN-gamma secretion and the intracellular response. We demonstrate in this study that a rechallenge with SEB becomes lethal only when given inside a critical time window after SEB priming and is associated with an increase of IFN-gamma serum release 72 h after priming. However, at this time, a selective blockade of IFN-gamma/STAT1 signaling develops in spleen cells, correlating with a lack of expression of the IFN-gamma receptor beta subunit and STAT1 in the T-cell population. Selective blockade of the STAT1 signaling pathway--while simultaneously maintaining STAT3 signaling and expression--may be a protective mechanism that shortens IFN-gamma production during the Th1 effector response. This blockade may also have consequences on switching towards a suppressor phenotype with chronic exposure to the superantigen.
AuthorsR Plaza, J L Rodriguez-Sanchez, C Juarez
JournalInfection and immunity (Infect Immun) Vol. 75 Issue 1 Pg. 306-13 (Jan 2007) ISSN: 0019-9567 [Print] United States
PMID17074848 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antigens, Bacterial
  • Enterotoxins
  • Ligands
  • Receptors, Interferon
  • STAT1 Transcription Factor
  • Stat1 protein, mouse
  • Superantigens
  • interferon gamma receptor
  • enterotoxin B, staphylococcal
  • Interferon-gamma
Topics
  • Animals
  • Antigens, Bacterial (immunology)
  • Electrophoretic Mobility Shift Assay
  • Enterotoxins (immunology)
  • Escherichia coli (immunology)
  • Immune Tolerance
  • Interferon-gamma (biosynthesis)
  • Ligands
  • Lymphocyte Activation (immunology)
  • Mice
  • Mice, Inbred BALB C
  • Receptors, Interferon (biosynthesis)
  • Reverse Transcriptase Polymerase Chain Reaction
  • STAT1 Transcription Factor (immunology, metabolism)
  • Shock, Septic (immunology)
  • Signal Transduction (immunology)
  • Superantigens (immunology)
  • Th1 Cells (immunology)

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