Hexapeptides HLDF-6 and PEDF-6 restore memory in rats after chronic intracerebroventricular treatment with beta-amyloid peptide Abeta(25-35).

Abstract

Effects of homologous peptides HLDF-6 and PEDF-6 on behavior of animals with experimental Alzheimer's disease induced by chronic intracerebroventricular administration of beta-amyloid peptide Abeta(25-35) were studied in the zoosocial recognition test and Morris water maze. Peptides HLDF-6 and PEDF-6 possessed neuroprotective activity and counteracted the toxic effect of Abeta(25-35). Peptides HLDF-6 and PEDF-6 mainly improved long-term memory and working memory, respectively.

• Authors: Z I Storozheva, A T Proshin, S S Zhokhov, V V Sherstnev, I L Rodionov, V M Lipkin, I A Kostanyan
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 141 Issue 3 Pg. 319-22 (Mar 2006) ISSN: 0007-4888 [Print] United States
• PMID: 17073149 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Amyloid beta-Peptides
• Eye Proteins
• Nerve Growth Factors
• Oligopeptides
• Peptide Fragments
• Serpins
• amyloid beta-protein (25-35)
• pigment epithelium-derived factor
• threonyl-glycyl-glutamyl-asparaginyl-histidylarginine

Topics

• Amyloid beta-Peptides (administration & dosage)
• Animals
• Eye Proteins (administration & dosage, pharmacology)
• Injections, Intraventricular
• Male
• Memory (drug effects)
• Nerve Growth Factors (administration & dosage, pharmacology)
• Oligopeptides (administration & dosage, pharmacology)
• Peptide Fragments (administration & dosage)
• Rats
• Rats, Wistar
• Serpins (administration & dosage, pharmacology)