Expression of insulin-like growth factor binding protein-2 in gastric carcinoma and its relationship with cell proliferation.

Abstract

AIM:

To investigate the expression of insulin-like growth factor binding protein-2 (IGFBP-2) in gastric carcinoma and its clinical significance and to explore its relationship with cell proliferation.

METHODS:

Expressions of IGFBP-2 and Ki-67 in 118 cases of gastric carcinoma and 40 cases of normal gastric mucosa were detected by EnVision immunohistochemical technique.

RESULTS:

Expression of IGFBP-2 in gastric carcinoma was higher than that in normal gastric mucosa (P < 0.01). There was no difference between high- and low-grade gastric carcinoma (P > 0.05). Expression of IGFBP-2 in advanced gastric carcinoma was higher than that in early gastric carcinoma (P < 0.05). Expression of IGFBP-2 in gastric carcinoma with lymph node metastasis was higher than that without lymph node metastasis (P < 0.01). IGFBP-2 expression was a positively related to the clinical stage of gastric carcinoma (P < 0.01). There was a positive correlation between IGFBP-2 and Ki-67 (P < 0.05).

CONCLUSION:

IGFBP-2 may be involved in carcino-genesis and progression of gastric carcinoma by promoting cell proliferation.

• Authors: Liang-Hui Shi, Xiao-Qun Zhu, Guo-Hai Zhao, Ya-Bin Xia, Yi-Sheng Zhang
• Journal: World journal of gastroenterology (World J Gastroenterol) Vol. 12 Issue 39 Pg. 6285-9 (Oct 21 2006) ISSN: 1007-9327 [Print] United States
• PMID: 17072950 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Insulin-Like Growth Factor Binding Protein 2
• Ki-67 Antigen

Topics

• Adult
• Aged
• Cell Proliferation
• Disease Progression
• Female
• Gastric Mucosa (metabolism, pathology)
• Gene Expression Regulation, Neoplastic
• Humans
• Insulin-Like Growth Factor Binding Protein 2 (genetics, metabolism)
• Ki-67 Antigen (genetics, metabolism)
• Lymphatic Metastasis (pathology)
• Male
• Middle Aged
• Stomach Neoplasms (genetics, metabolism, pathology)