Abstract |
Peplomycin emulsified in hydroxypropyl cellulosum (HPC-PEP) was prepared for intravesical chemotherapy. Clinical efficacy of HPC-PEP and tissue concentration of peplomycin (PEP) were studied in 12 patients with bladder tumor. Histopathology showed transitional cell carcinoma; 2 in grade 1,8 in grade 2, and 2 in grade 3. The total volume of 30 ml HPC-PEP was prepared from a mixture of 2% HPC and 90 mg PEP in 15 ml saline, and was intravesically administered through a urethral catheter and retained for two hours. Clinical evaluation 7 days after the initial instillation demonstrated good tumor regression in 2, good response in 5, and no change in 5. The mean PEP level in tumor tissue was 0.36 microgram/gr after 7 days and 0.19 microgram/gr even after 14 days. These clinical observations and tissue levels of PEP suggest that HPC-PEP might be useful as an intravesical instillation agent for bladder tumor.
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Authors | A Horii, M Kyo, R Yasumoto, M Asakawa, Y Morikawa, S Tanaka, K Kakinoki, T Kishimoto, M Maekawa |
Journal | Hinyokika kiyo. Acta urologica Japonica
(Hinyokika Kiyo)
Vol. 37
Issue 1
Pg. 21-4
(Jan 1991)
ISSN: 0018-1994 [Print] Japan |
PMID | 1707215
(Publication Type: Journal Article)
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Chemical References |
- Delayed-Action Preparations
- Emulsions
- Bleomycin
- Peplomycin
- Cellulose
- hydroxypropylcellulose
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Topics |
- Administration, Intravesical
- Adult
- Aged
- Bleomycin
(administration & dosage, blood, pharmacokinetics)
- Carcinoma, Transitional Cell
(drug therapy, metabolism, pathology)
- Cellulose
(administration & dosage, analogs & derivatives)
- Delayed-Action Preparations
- Emulsions
- Female
- Humans
- Male
- Middle Aged
- Peplomycin
- Urinary Bladder
(metabolism)
- Urinary Bladder Neoplasms
(drug therapy, metabolism, pathology)
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