[Clinical effect on tumor regression and tissue concentration of peplomycin treated with peplomycin emulsion in hydroxypropylcellulosum].

Abstract

Peplomycin emulsified in hydroxypropyl cellulosum (HPC-PEP) was prepared for intravesical chemotherapy. Clinical efficacy of HPC-PEP and tissue concentration of peplomycin (PEP) were studied in 12 patients with bladder tumor. Histopathology showed transitional cell carcinoma; 2 in grade 1,8 in grade 2, and 2 in grade 3. The total volume of 30 ml HPC-PEP was prepared from a mixture of 2% HPC and 90 mg PEP in 15 ml saline, and was intravesically administered through a urethral catheter and retained for two hours. Clinical evaluation 7 days after the initial instillation demonstrated good tumor regression in 2, good response in 5, and no change in 5. The mean PEP level in tumor tissue was 0.36 microgram/gr after 7 days and 0.19 microgram/gr even after 14 days. These clinical observations and tissue levels of PEP suggest that HPC-PEP might be useful as an intravesical instillation agent for bladder tumor.

• Authors: A Horii, M Kyo, R Yasumoto, M Asakawa, Y Morikawa, S Tanaka, K Kakinoki, T Kishimoto, M Maekawa
• Journal: Hinyokika kiyo. Acta urologica Japonica (Hinyokika Kiyo) Vol. 37 Issue 1 Pg. 21-4 (Jan 1991) ISSN: 0018-1994 [Print] Japan
• PMID: 1707215 (Publication Type: Journal Article)

Chemical References

• Delayed-Action Preparations
• Emulsions
• Bleomycin
• Peplomycin
• Cellulose
• hydroxypropylcellulose

Topics

• Administration, Intravesical
• Adult
• Aged
• Bleomycin (administration & dosage, blood, pharmacokinetics)
• Carcinoma, Transitional Cell (drug therapy, metabolism, pathology)
• Cellulose (administration & dosage, analogs & derivatives)
• Delayed-Action Preparations
• Emulsions
• Female
• Humans
• Male
• Middle Aged
• Peplomycin
• Urinary Bladder (metabolism)
• Urinary Bladder Neoplasms (drug therapy, metabolism, pathology)