[Enhancement of nonsteroidal, anti-inflammatory drugs and preventive effect of antihistamines and disodium cromoglycate on wheat allergy].

Abstract

BACKGROUND:

Aspirin has been known to be an enhancer to wheat allergy, including wheat-dependent, exercise-induced anaphylaxis.

OBJECTIVE:

To investigate whether nonsteroidal, anti-inflammatory drugs (NSAIDs) other than aspirin would enhance allergic reactions after wheat ingestion and whether antihistamines and disodium cromoglycate would prevent these reactions.

METHODS:

Seven cases, whose reactions after wheat ingestion were enhanced by aspirin on challenge tests, were enrolled. Skin prick tests (SPT) and CAP-RAST were undergone for wheat and gluten. We used challenge tests of wheat after pretreatment of NSAIDs and preventive drugs.

RESULTS:

Four cases were diagnosed with wheat allergy, 3 cases had wheat-dependent, salicylic acid-induced anaphylaxis. SPT and CAP-RAST were positive for wheat and gluten in 5 of 7 cases and 4 of 7 cases, respectively. Dicrofenac enhanced the allergic reactions after wheat ingestion in 1 of 2 cases, whereas etodolac failed to enhance the symptoms in all 5 cases performed. Furthermore, disodium cromoglycate could not completely prevent the allergic reaction in all 4 cases and even enhanced the reaction in 1 case of them. To see an inhibitory effect of antihistamines on the symptoms, fexofenadine (in 2, 1 and 1 case, respectively), olopatadine, and chlorpheniramine were administrated before the challenge test, and as a result these drugs were found to have inhibitory effects on the allergic reaction.

CONCLUSION:

In this study, it was suggested that etodolac might be a relatively safe anti-inflammatory drug on wheat allergy and antihistamines could prevent allergic reactions more than DSCG in patients with wheat allergy.

• Authors: Naoko Inomata, Kazuko Nakamura, Yumiko Yamane, Hiroyuki Fujita, Momoko Takakura, Mariko Sugawara, Hiroyuki Osuna, Zenro Ikezawa
• Journal: Arerugi = [Allergy] (Arerugi) Vol. 55 Issue 10 Pg. 1304-11 (Oct 2006) ISSN: 0021-4884 [Print] Japan
• PMID: 17072110 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Histamine H1 Antagonists
• Cromolyn Sodium
• Aspirin

Topics

• Adult
• Aged
• Anaphylaxis (etiology)
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
• Aspirin (adverse effects)
• Cromolyn Sodium (therapeutic use)
• Exercise
• Female
• Histamine H1 Antagonists (therapeutic use)
• Humans
• Male
• Middle Aged
• Wheat Hypersensitivity (immunology, prevention & control)