Leptin receptor gene polymorphisms in severely pre-eclamptic women.

Abstract

Variants of the leptin receptor gene (LEPR) may modulate the effect of elevated serum leptin levels in pre-eclampsia. The aim of our study was to evaluate the LEPR gene polymorphisms Lys109Arg (A109G) and Gln223Arg (A223G) in severely pre-eclamptic women. In a case-control study, we analyzed blood samples from 124 severely pre-eclamptic patients and 107 healthy control women by the polymerase chain reaction-restriction fragment length polymorphism method. The Pearson chi2 test was used to estimate odds ratios (OR) and 95% confidence intervals (CI). The association was adjusted for maternal age, pre-pregnancy body mass index and primiparity with logistic regression analysis. Pregnant women with the LEPR 223G allele (223A/G or 223G/G genotype) had almost double the risk of developing severe pre-eclampsia compared with patients with the 223A/A genotype (adjusted OR = 1.92, 95% CI: 1.07-3.41). Genotype variants of LEPR A109G alone did not affect the risk of severe pre-eclampsia. Haplotype estimation of A109G and A223G polymorphisms of the LEPR gene revealed that the G-A haplotype versus other pooled haplotypes was significantly less common in the pre-eclamptic group (p < 0.01), while the G-G haplotype versus others was overrepresented among severely pre-eclamptic patients (p < 0.01), compared with controls. In conclusion, our data indicate that LEPR A223G polymorphism may individually modify the risk of severe pre-eclampsia.

• Authors: János Rigó, György Szendei, Klára Rosta, Andrea Fekete, Krisztina Bögi, Attila Molvarec, Zsolt Rónai, Agota Vér
• Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology (Gynecol Endocrinol) Vol. 22 Issue 9 Pg. 521-5 (Sep 2006) ISSN: 0951-3590 [Print] England
• PMID: 17071538 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• LEPR protein, human
• Receptors, Cell Surface
• Receptors, Leptin

Topics

• Adolescent
• Adult
• Female
• Genotype
• Humans
• Polymorphism, Genetic (genetics)
• Pre-Eclampsia (genetics, pathology)
• Pregnancy
• Receptors, Cell Surface (genetics)
• Receptors, Leptin