HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Anhidrosis: a clue to an underlying autonomic disorder.

Abstract
We describe a patient with Ross syndrome who had the classic triad of segmental anhidrosis, tonic pupils and hyporeflexia. Dilute pilocarpine (0.1%) instillation in both eyes revealed parasympathetic denervation hypersensitivity. There was evidence of cardiac dysautonomia in the form of a decrease in heart rate variability with deep breathing and an abnormal Valsalva response. A thermoregulatory sweat test showed the presence of sweating in the right cheek, neck and upper one-third of the left arm and shoulder only. Sympathetic skin responses were absent in the affected segments of the upper limb. Ross syndrome is a degenerative disorder that progressively involves different fibre populations, starting with autonomic fibres and then involving the unmyelinated and myelinated sensory fibres. A careful clinical examination and simple bedside autonomic tests can confirm the diagnosis.
AuthorsThomas Chemmanam, Jeyaraj D Pandian, Randhir S Kadyan, S M Bhatti
JournalJournal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia (J Clin Neurosci) Vol. 14 Issue 1 Pg. 94-6 (Jan 2007) ISSN: 0967-5868 [Print] Scotland
PMID17070054 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Miotics
  • Pilocarpine
Topics
  • Adult
  • Autonomic Nervous System Diseases (complications, diagnosis)
  • Blood Pressure (drug effects)
  • Humans
  • Hypohidrosis (diagnosis, etiology)
  • Male
  • Miotics
  • Neural Conduction
  • Pilocarpine
  • Pupil (physiology)
  • Reflex, Abnormal (physiology)
  • Syndrome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: