Abstract | INTRODUCTION: MATERIALS AND METHODS: Retrospective study of 115 premature infants with respiratory distress syndrome born and treated at Odense University Hospital during the years 1999 to 2004. The criterion for surfactant treatment was a decrease in the arterial/alveolar oxygen tension ratio (or corresponding values for the fraction of inspired oxygen) below 0.36 in infants with gestational age (GA) < 30 weeks and 0.22 in more mature infants. RESULTS: The primary end point was survival during the first week of life without mechanical ventilation. This end point was reached by 51% of the infants with GA < 30 weeks. However, the effect proved to be GA-dependent, increasing from 22% in infants with a GA of 24-25 weeks to 86% in week 29. Seventy percent survived to be discharged. In infants with GA > 29 weeks the effect was 87%, and all survived. CONCLUSION: The effect of surfactant therapy administered per the INSURE method is GA-dependent, and the method works best after GA week 25. The question is whether earlier therapy will increase its efficiency or the method has reached its limit.
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Authors | Tina Andersen, Hanne Spangsberg Holm, Jens Kamper |
Journal | Ugeskrift for laeger
(Ugeskr Laeger)
Vol. 168
Issue 43
Pg. 3723-7
(Oct 23 2006)
ISSN: 1603-6824 [Electronic] Denmark |
Vernacular Title | Surfaktantbehandling af nyfødte børn i continuous positive airway pressure-behandling. |
PMID | 17069738
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Biological Products
- Phospholipids
- Pulmonary Surfactants
- poractant alfa
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Topics |
- Biological Products
(administration & dosage)
- Continuous Positive Airway Pressure
- Gestational Age
- Humans
- Infant, Newborn
- Infant, Premature
- Phospholipids
(administration & dosage)
- Pulmonary Surfactants
(administration & dosage)
- Respiratory Distress Syndrome, Newborn
(drug therapy, therapy)
- Retrospective Studies
- Treatment Outcome
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