Tibolone and breast cancer.

Abstract

Tibolone is a relatively new drug for postmenopausal women, which is structurally related to 19-nortestosterone derivatives and exhibits weak oestrogenic, progestogenic and androgenic activities. The effect of tibolone on breast tissue is still obscure. In vitro studies have shown conflicting results regarding the effects of tibolone on breast cells. On the other hand, although epidemiological studies show an increase in the risk of breast cancer among women treated with tibolone, accumulation of data obtained from radiological studies presents promising results. However, the safety of tibolone with regard to breast tissue needs to be investigated further, especially through well-designed, large-scale, randomised-controlled trials.

• Authors: C Tamer Erel, Levent M Senturk, Semih Kaleli
• Journal: Postgraduate medical journal (Postgrad Med J) Vol. 82 Issue 972 Pg. 658-62 (Oct 2006) ISSN: 1469-0756 [Electronic] England
• PMID: 17068276 (Publication Type: Journal Article, Review)

Chemical References

• Antineoplastic Agents, Hormonal
• Norpregnenes
• tibolone

Topics

• Animals
• Antineoplastic Agents, Hormonal (therapeutic use)
• Breast Neoplasms (diagnostic imaging, drug therapy, pathology)
• Female
• Humans
• Macaca fascicularis
• Norpregnenes (therapeutic use)
• Radiography
• Rats