Gymnastatins F-H, cytostatic metabolites from the sponge-derived fungus Gymnascella dankaliensis.

Abstract

Gymnastatins F -H (2-4) and gymnamide (5) have been isolated from the mycelial MeOH extract of the Halichondria sponge-derived fungus Gymnascella dankaliensis. Their stereostructures have been established on the basis of spectroscopic analyses using 1D and 2D NMR techniques. The stereochemistry of gymnastatin H (4) was determined by its synthesis. Among these compounds, gymnastatins F (2) and G (3) possess a unique bicyclo[3.3.1]nonane ring as natural products, and they were found to exhibit potent growth inhibition against the P388 cancer cell line.

• Authors: Taro Amagata, Katsuhiko Minoura, Atsushi Numata
• Journal: Journal of natural products (J Nat Prod) Vol. 69 Issue 10 Pg. 1384-8 (Oct 2006) ISSN: 0163-3864 [Print] United States
• PMID: 17067147 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Bridged-Ring Compounds
• Phenols
• gymnastatin F
• gymnastatin G
• gymnastatin H

Topics

• Animals
• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Ascomycota (chemistry)
• Bridged-Ring Compounds (chemistry, isolation & purification, pharmacology)
• Drug Screening Assays, Antitumor
• Japan
• Leukemia P388
• Mice
• Molecular Structure
• Phenols (chemistry, isolation & purification, pharmacology)
• Porifera (microbiology)