Evaluation of the clinical efficacy of benazepril in the treatment of chronic renal insufficiency in cats.

Abstract

BACKGROUND:

Chronic renal insufficiency (CRI) is a common disease in cats. Angiotensin-converting enzyme inhibitors (ACEI) have beneficial effects in humans with CRI by reducing the loss of protein in the urine and increasing life expectancy.

HYPOTHESIS:

The ACEI benazepril has beneficial effects on survival, clinical variables, or both as compared with placebo in cats with CRI.

ANIMALS:

61 cats with naturally occurring CRI.

METHODS:

The cats were enrolled into a prospective, randomized, double-blind, placebo-controlled clinical trial. Cats received placebo or 0.5-1 mg/kg benazepril once daily for up to 6 months.

RESULTS:

Urine protein/urine creatinine ratios were significantly (P < .05) lower with benazepril as compared with placebo at days 120 and 180. Three cats with placebo and 1 cat with benazepril were removed prematurely from the study because of deterioration of CRI or death. Cats were classified into 4 stages of CRI according to the International Renal Interest Society (IRIS) classification scheme. Incidence rates of cats with IRIS classification stage 2 or stage 3 that remained in stage 2 or 3 without progressing to stage 4 were higher with benazepril (93 +/- 5%) as compared with placebo (73 +/- 13%).

CLINICAL IMPORTANCE:

These results suggest a potential for benazepril to delay the progression of disease, extend survival time, or both in cats with CRI.

• Authors: Hisashi Mizutani, Hidekazu Koyama, Toshifumi Watanabe, Hitoshi Kitagawa, Masakazu Nakano, Keita Kajiwara, Jonathan N King
• Journal: Journal of veterinary internal medicine (J Vet Intern Med) 2006 Sep-Oct Vol. 20 Issue 5 Pg. 1074-9 ISSN: 0891-6640 [Print] United States
• PMID: 17063698 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Angiotensin-Converting Enzyme Inhibitors
• Benzazepines
• Creatinine
• benazepril

Topics

• Angiotensin-Converting Enzyme Inhibitors (therapeutic use)
• Animals
• Benzazepines (therapeutic use)
• Blood Urea Nitrogen
• Cat Diseases (blood, drug therapy, urine)
• Cats
• Creatinine (blood, urine)
• Double-Blind Method
• Female
• Kidney Failure, Chronic (blood, drug therapy, urine, veterinary)
• Male
• Prospective Studies
• Proteinuria (veterinary)
• Quality of Life
• Survival Analysis