Abstract |
In this pilot study, the preliminary effectiveness of a composite graft consisting of demineralized bone matrix (DBM) putty ( Grafton DBM) and aspirated bone marrow was evaluated for treating long bone fractures. Patients were ssigned randomly to treatment with the DBM putty composite (n = 10) or iliac crest autograft (n = 8), and had a minimum of 12 months of radiographic follow-up. Ninety percent of DBM patients (9/10) achieved full bone formation compared to 75% of autograft patients (6/8) (P = .41). Additionally, all 10 DBM patients were healed compared with 63% of autograft patients (5/8) (P = .07). These findings suggest that DBM putty enriched with bone marrow may be comparable to autograft for treating long bone fractures.
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Authors | Ronald W Lindsey, George W Wood, Kalia K Sadasivian, Harrison A Stubbs, Jon E Block |
Journal | Orthopedics
(Orthopedics)
Vol. 29
Issue 10
Pg. 939-41
(10 2006)
ISSN: 0147-7447 [Print] United States |
PMID | 17061421
(Publication Type: Journal Article, Randomized Controlled Trial)
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Topics |
- Adult
- Aged
- Bone Demineralization Technique
(methods)
- Bone Marrow
(metabolism)
- Bone Matrix
(metabolism)
- Bone Transplantation
(methods)
- Female
- Follow-Up Studies
- Fractures, Bone
(diagnostic imaging, surgery)
- Humans
- Male
- Middle Aged
- Pilot Projects
- Radiography
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