Abstract | OBJECTIVE: METHOD: Subjects received an course of at least 7-day dexamethasone [5 g/(L x d)] intratympanic injection. Pure-tone averages (PTA) calculated using air conduction thresholds at 4 -frequencies (500, 1000, 2000, 4000 Hz) at pre-injection and post-injection were compared. The change in PTA greater than 10 dB HL was considered to be effective. RESULT: PTA at pre-injection and post-injection were (65.65 +/- 24.73) dB HL and (50.25 +/- 25.59)dB HL respectively in 21 patients with sudden sensorineural hearing loss. There was significant improvement in PTA (P < 0.01). Improvement in hearing was found in 47.6% patients. Promising results of intratympanic dexamethasone medication were found in cases with shorter duration or/and without vertigo. No unexpected adverse events such as otitis media or perforated tympanic membrane or worsening in hearing occurred during the injection or follow-up period. CONCLUSION:
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Authors | Jun Shi, Jun Yang, Hao Wu, Bin Xue, Xiangping Chen, Rongping Cao, Guozhen Meng, Mingliang Xiang, Qi Huang |
Journal | Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
(Lin Chuang Er Bi Yan Hou Ke Za Zhi)
Vol. 20
Issue 16
Pg. 749-51
(Aug 2006)
China |
PMID | 17058923
(Publication Type: Clinical Trial, English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Aged
- Dexamethasone
(administration & dosage, therapeutic use)
- Female
- Hearing Loss, Sudden
(drug therapy)
- Humans
- Injections, Intralesional
- Male
- Middle Aged
- Treatment Outcome
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