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[Intratympanic dexamethasone medication for sudden sensorineural hearing loss: clinical evaluation].

AbstractOBJECTIVE:
To investigate clinical efficacy of intratympanic dexamethasone injection for sudden sensorineural hearing loss.
METHOD:
Subjects received an course of at least 7-day dexamethasone [5 g/(L x d)] intratympanic injection. Pure-tone averages (PTA) calculated using air conduction thresholds at 4 -frequencies (500, 1000, 2000, 4000 Hz) at pre-injection and post-injection were compared. The change in PTA greater than 10 dB HL was considered to be effective.
RESULT:
PTA at pre-injection and post-injection were (65.65 +/- 24.73) dB HL and (50.25 +/- 25.59)dB HL respectively in 21 patients with sudden sensorineural hearing loss. There was significant improvement in PTA (P < 0.01). Improvement in hearing was found in 47.6% patients. Promising results of intratympanic dexamethasone medication were found in cases with shorter duration or/and without vertigo. No unexpected adverse events such as otitis media or perforated tympanic membrane or worsening in hearing occurred during the injection or follow-up period.
CONCLUSION:
Intratympanic dexamethasone medication can be beneficial in treating patient with sudden sensorineural hearing loss. Duration and vertigo are two important factors for prognosis.
AuthorsJun Shi, Jun Yang, Hao Wu, Bin Xue, Xiangping Chen, Rongping Cao, Guozhen Meng, Mingliang Xiang, Qi Huang
JournalLin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology (Lin Chuang Er Bi Yan Hou Ke Za Zhi) Vol. 20 Issue 16 Pg. 749-51 (Aug 2006) China
PMID17058923 (Publication Type: Clinical Trial, English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Dexamethasone
Topics
  • Adult
  • Aged
  • Dexamethasone (administration & dosage, therapeutic use)
  • Female
  • Hearing Loss, Sudden (drug therapy)
  • Humans
  • Injections, Intralesional
  • Male
  • Middle Aged
  • Treatment Outcome

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