[Assessment on effects of tongjiang granule on experimental reflux esophagitis in rats].

Abstract

OBJECTIVE:

To study the effects of tongjiang granule (TJG) on reflux esophagitis (RE) in rats.

METHODS:

Two rat models of RE were established respectively by cardioplasty + pyloric ligation + Roux-en-Y gastro-jejunum anastomosis and by placed a fixed steel ring into the gastric cardia, and the model rats were treated with various dosages of TJG or cisapride by gastric perfusion.

RESULTS:

Rat models were established successfully by both methods. The score of pathological changes of esophagus mucosa in the model rats, made by either method, after high-dosage TJG treatment was lower than that in the model rats (P < 0.05), but equal to that in the cisapride treated model rats. High and moderate dosages of TJG were shown by transmission electron microscope to have effects of alleviating heckle cells and inflammatory reaction. They could reduce the level of gastric acid, more significant in high and moderate dosage groups (P < 0.05), while cisapride couldn't.

CONCLUSION:

TJG is effective in treating experimental RE in rats to a certain extent.

• Authors: Xu-dong Tang, Hong-mei Wu, Zhi-bin Wang
• Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 26 Issue 9 Pg. 818-21 (Sep 2006) ISSN: 1003-5370 [Print] China
• PMID: 17058833 (Publication Type: English Abstract, Journal Article)

Chemical References

• Drugs, Chinese Herbal
• Powders
• tongjiang

Topics

• Animals
• Drugs, Chinese Herbal (therapeutic use)
• Esophagitis, Peptic (drug therapy, pathology)
• Esophagus (drug effects, pathology)
• Female
• Male
• Phytotherapy
• Powders
• Random Allocation
• Rats
• Rats, Sprague-Dawley