Abstract |
Ethylbenzene was administered to groups of male and female Wistar rats by gavage for 4 (n = 5/dose/sex) and 13 weeks (n = 10/dose/sex) (OECD 408) at doses of 0 (vehicle control), 75, 250, and 750 mg/kg bodyweight/day (mg/kg bw/day), administered am/pm as half doses. In the 4-week study, > or =250 mg/kg increased serum alanine aminotransferase, total bilirubin and cholesterol, liver weights and centrilobular hepatocyte hypertrophy, and kidney weights; males also had post-dose salivation, increased urinary epithelial cell casts and cells, and hyaline droplet nephropathy. In the 13-week study, > or =250 mg/kg increased water consumption and produced post-dose salivation. Liver-related effects: increased serum alanine aminotransferase, gamma-glutamyltransferase, bilirubin, total protein, albumin and globulins, cholesterol, liver weights and centrilobular hepatocyte hypertrophy, and reduced prothrombin times. Kidney-related effects: increased serum potassium, calcium, magnesium, kidney weights, and (males only) urea and hyaline droplets in renal tubular epithelium, and reduced sodium (females only); creatinine was reduced in 750 mg/kg males. The NOAEL of ethylbenzene in these studies, based on hepatocyte hypertrophy and liver- and kidney-related clinical chemistry changes, was 75 mg/kg bw/day.
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Authors | Werner Mellert, Klaus Deckardt, Wolfgang Kaufmann, Bennard van Ravenzwaay |
Journal | Archives of toxicology
(Arch Toxicol)
Vol. 81
Issue 5
Pg. 361-70
(May 2007)
ISSN: 0340-5761 [Print] Germany |
PMID | 17058104
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Benzene Derivatives
- Urea
- Cholesterol
- Alanine Transaminase
- ethylbenzene
- Bilirubin
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Topics |
- Administration, Oral
- Alanine Transaminase
(blood)
- Animals
- Behavior, Animal
(drug effects)
- Benzene Derivatives
(administration & dosage, chemistry, toxicity)
- Bilirubin
(blood)
- Body Weight
(drug effects)
- Cholesterol
(blood)
- Dose-Response Relationship, Drug
- Drinking
(drug effects)
- Eating
(drug effects)
- Erythrocyte Indices
(drug effects)
- Female
- Kidney
(drug effects, pathology)
- Liver
(drug effects, pathology)
- Male
- Motor Activity
(drug effects)
- Organ Size
(drug effects)
- Rats
- Rats, Wistar
- Salivation
(drug effects)
- Thymus Gland
(drug effects, pathology)
- Time Factors
- Toxicity Tests
(methods, standards)
- Urea
(blood)
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