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Ethylbenzene: 4- and 13-week rat oral toxicity.

Abstract
Ethylbenzene was administered to groups of male and female Wistar rats by gavage for 4 (n = 5/dose/sex) and 13 weeks (n = 10/dose/sex) (OECD 408) at doses of 0 (vehicle control), 75, 250, and 750 mg/kg bodyweight/day (mg/kg bw/day), administered am/pm as half doses. In the 4-week study, > or =250 mg/kg increased serum alanine aminotransferase, total bilirubin and cholesterol, liver weights and centrilobular hepatocyte hypertrophy, and kidney weights; males also had post-dose salivation, increased urinary epithelial cell casts and cells, and hyaline droplet nephropathy. In the 13-week study, > or =250 mg/kg increased water consumption and produced post-dose salivation. Liver-related effects: increased serum alanine aminotransferase, gamma-glutamyltransferase, bilirubin, total protein, albumin and globulins, cholesterol, liver weights and centrilobular hepatocyte hypertrophy, and reduced prothrombin times. Kidney-related effects: increased serum potassium, calcium, magnesium, kidney weights, and (males only) urea and hyaline droplets in renal tubular epithelium, and reduced sodium (females only); creatinine was reduced in 750 mg/kg males. The NOAEL of ethylbenzene in these studies, based on hepatocyte hypertrophy and liver- and kidney-related clinical chemistry changes, was 75 mg/kg bw/day.
AuthorsWerner Mellert, Klaus Deckardt, Wolfgang Kaufmann, Bennard van Ravenzwaay
JournalArchives of toxicology (Arch Toxicol) Vol. 81 Issue 5 Pg. 361-70 (May 2007) ISSN: 0340-5761 [Print] Germany
PMID17058104 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Benzene Derivatives
  • Urea
  • Cholesterol
  • Alanine Transaminase
  • ethylbenzene
  • Bilirubin
Topics
  • Administration, Oral
  • Alanine Transaminase (blood)
  • Animals
  • Behavior, Animal (drug effects)
  • Benzene Derivatives (administration & dosage, chemistry, toxicity)
  • Bilirubin (blood)
  • Body Weight (drug effects)
  • Cholesterol (blood)
  • Dose-Response Relationship, Drug
  • Drinking (drug effects)
  • Eating (drug effects)
  • Erythrocyte Indices (drug effects)
  • Female
  • Kidney (drug effects, pathology)
  • Liver (drug effects, pathology)
  • Male
  • Motor Activity (drug effects)
  • Organ Size (drug effects)
  • Rats
  • Rats, Wistar
  • Salivation (drug effects)
  • Thymus Gland (drug effects, pathology)
  • Time Factors
  • Toxicity Tests (methods, standards)
  • Urea (blood)

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