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An estrogen receptor-beta agonist is active in models of inflammatory and chemical-induced pain.

Abstract
ERB-041 (2-(3-Fluoro-4-hydroxyphenyl)-7-vinyl-1,3 benzoxazol-5-ol) is a selective estrogen receptor-beta agonist with activity in rodent models of rheumatoid arthritis and endometriosis. Clinical trials for these diseases are underway: however, the role of estrogen receptor-beta in modulating pain associated with inflammation remains unknown. These studies demonstrate that acutely administered ERB-041 is anti-hyperalgesic in preclinical models of chemical-induced and acute inflammatory pain, thus suggesting that ERB-041 may be useful for modulating pain associated with some types of inflammation.
AuthorsLiza Leventhal, Michael R Brandt, Terri A Cummons, Michael J Piesla, Kathryn E Rogers, Heather A Harris
JournalEuropean journal of pharmacology (Eur J Pharmacol) Vol. 553 Issue 1-3 Pg. 146-8 (Dec 28 2006) ISSN: 0014-2999 [Print] Netherlands
PMID17056036 (Publication Type: Journal Article)
Chemical References
  • ERB 041
  • Estrogen Receptor beta
  • Oxazoles
  • Fulvestrant
  • Estradiol
Topics
  • Animals
  • Dose-Response Relationship, Drug
  • Estradiol (analogs & derivatives, pharmacology)
  • Estrogen Receptor beta (agonists)
  • Fulvestrant
  • Hot Temperature
  • Hyperalgesia (drug therapy)
  • Inflammation (chemically induced, complications)
  • Male
  • Oxazoles (pharmacology)
  • Pain (chemically induced, etiology)
  • Rats
  • Rats, Sprague-Dawley

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