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Analysis of DC-SIGN (CD209) functional variants in patients with tuberculosis.

Abstract
Several lines of evidence suggest that host genetic factors controlling the immune response influence infection by Mycobacterium tuberculosis. Recently, DC-SIGN has been shown to be the major M. tuberculosis receptor on dendritic cells (DCs). The aim of this study was to investigate the influence of DC-SIGN functional polymorphisms -336G/A SNP in the promoter region and insertion/deletion in the "neck" region on the predisposition to tuberculosis. We performed an association study in 110 HIV-negative tuberculosis patients and 299 matched controls. In addition, a total of 155 healthy controls were screened for the tuberculin skin test (TST). DC-SIGN -336 SNP detection was performed by the real-time polymerase chain reaction technology, using the TaqMan 5' allele. The insertion/deletion in the "neck" region was analyzed by polymerase chain reaction with specific primers. Although an increased frequency of the G allele in tuberculosis patients (23%), as compared with controls (19%), was observed, differences were not statistically significant (OR = 1.31, 95% CI = 0.89-1.94, P = 0.14). On the other hand, DC-SIGN repeat polymorphism in the "neck" region had a very low frequency in the analyzed population. We conclude that the studied polymorphisms are not relevant risk factors for developing tuberculosis in Northwestern Colombian individuals.
AuthorsLuis M Gómez, Juan-Manuel Anaya, Elena Sierra-Filardi, Jose Cadena, Angel Corbí, Javier Martín
JournalHuman immunology (Hum Immunol) Vol. 67 Issue 10 Pg. 808-11 (Oct 2006) ISSN: 0198-8859 [Print] United States
PMID17055357 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Cell Adhesion Molecules
  • DC-specific ICAM-3 grabbing nonintegrin
  • Lectins, C-Type
  • Receptors, Cell Surface
Topics
  • Adult
  • Cell Adhesion Molecules (genetics, immunology)
  • Colombia
  • Female
  • Gene Frequency
  • Genotype
  • Heterozygote
  • Homozygote
  • Humans
  • Hypersensitivity, Delayed (genetics, immunology)
  • Lectins, C-Type (genetics, immunology)
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide (genetics)
  • Receptors, Cell Surface (genetics, immunology)
  • Tuberculosis (genetics, immunology)
  • Tuberculosis, Pulmonary (genetics, immunology)

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