Not all eicosanoids are bad.

Abstract

Although considerable attention has been focused on elucidating the factors that drive inflammation, it is becoming clear that this "acceleration" state is offset by an internal "handbrake". A recent study has uncovered an essential component of this handbrake system, revealing that lipoxins trigger suppressors of cytokine signalling to dampen inflammatory responses to infection. This work bolsters the growing interest in understanding how inflammation is controlled from within and draws further attention to novel targets for drug development based on mimicking the actions of endogenous anti-inflammatory and pro-resolution signals.

• Authors: Thea Morris, Ravindra Rajakariar, Melanie Stables, Derek W Gilroy
• Journal: Trends in pharmacological sciences (Trends Pharmacol Sci) Vol. 27 Issue 12 Pg. 609-11 (Dec 2006) ISSN: 0165-6147 [Print] England
• PMID: 17055068 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Inflammation Mediators
• Lipoxins
• lipoxin A4

Topics

• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Humans
• Inflammation (prevention & control)
• Inflammation Mediators (metabolism, physiology)
• Lipoxins (metabolism, physiology)
• Parasitic Diseases (metabolism)