Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: SUMMARY: The cystic fibrosis community is working to identify the most important gene modifiers for lung disease. Candidate genes are currently being tested, and high-resolution, whole-genome scans are now affordable. For cystic fibrosis, several hundred thousand genetic markers (single-nucleotide polymorphisms) will identify key chromosomal regions and genes. If successful, these studies will provide the opportunity for novel approaches and therapies for cystic fibrosis lung disease.
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Authors | Michael R Knowles |
Journal | Current opinion in pulmonary medicine
(Curr Opin Pulm Med)
Vol. 12
Issue 6
Pg. 416-21
(Nov 2006)
ISSN: 1070-5287 [Print] United States |
PMID | 17053491
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
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Topics |
- Cystic Fibrosis
(complications, genetics)
- Genes, Recessive
- Genetic Heterogeneity
- Genetic Variation
- Genome, Human
- Humans
- Lung Diseases
(etiology, physiopathology)
- Severity of Illness Index
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