Hinokiresinol inhibits IgE-induced mouse passive cutaneous anaphylaxis reaction.

Abstract

The antiallergic effect of hinokiresinol isolated from the whole plant of TRAPA Pseudoincisa S. at. Z. was measured in vitro and in vivo. Hinokiresinol not only potently inhibited beta-hexosaminidase release from RBL-2H3 cells induced by IgE, with an IC50 value of 98 microM, but also inhibited the proinflammatory cytokines IL-6, IL-4 and TNF-alpha in RBL-2H3 cells stimulated by IgE. Orally and intraperitoneally administered hinokiresinol potently inhibited the passive anaphylaxis reaction in mice induced by IgE.

• Authors: Eun-Ah Bae, Eun-Kyung Park, Hye-Joung Yang, Nam-In Baek, Dong-Hyun Kim
• Journal: Planta medica (Planta Med) Vol. 72 Issue 14 Pg. 1328-30 (Nov 2006) ISSN: 0032-0943 [Print] Germany
• PMID: 17051467 (Publication Type: Journal Article)

Chemical References

• Anti-Allergic Agents
• Lignans
• Phenols
• hinokiresinol
• Leukotriene B4
• Immunoglobulin E

Topics

• Administration, Oral
• Animals
• Anti-Allergic Agents (administration & dosage, pharmacology, therapeutic use)
• Dose-Response Relationship, Drug
• Immunoglobulin E
• Inhibitory Concentration 50
• Injections, Intraperitoneal
• Leukotriene B4 (antagonists & inhibitors)
• Lignans (administration & dosage, pharmacology, therapeutic use)
• Magnoliopsida
• Male
• Mice
• Mice, Inbred ICR
• Passive Cutaneous Anaphylaxis (drug effects)
• Phenols (administration & dosage, pharmacology, therapeutic use)
• Phytotherapy