Potent antitumor activity of 3,4-seco-8betaH-Ferna-4(23),9(11)-dien-3-oic acid (EC-2) and 3,4-seco-Oleana-4(23),18-dien-3-oic acid (EC-4), evaluated by an in vitro human cancer cell line panel.

Abstract

3,4-seco-8beta H-Ferna-4(23),9(11)-dien-3-oic acid (EC-2) (1) and 3,4-seco-oleana-4(23),18-dien-3-oic acid (EC-4) (2) isolated from the whole herb of Euphorbia chamaesyce L. were evaluated for their anti-tumor activities using a panel including 39 human cancer cell lines (HCC) coupled with a drug sensitivity database. Compounds 1 and 2 showed strong cytotoxicity against the HCC panel, even though alcohols 1A and 2A and methyl esters 1B and 2B were inactive.

• Authors: Reiko Tanaka, Shun-ichi Wada, Takeshi Yamada, Takao Yamori
• Journal: Planta medica (Planta Med) Vol. 72 Issue 14 Pg. 1347-9 (Nov 2006) ISSN: 0032-0943 [Print] Germany
• PMID: 17051463 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Plant Extracts

Topics

• Antineoplastic Agents, Phytogenic (administration & dosage, pharmacology, therapeutic use)
• Cell Line, Tumor (drug effects)
• Euphorbia
• Humans
• Phytotherapy
• Plant Extracts (administration & dosage, pharmacology, therapeutic use)