Abstract | PURPOSE: MATERIAL AND METHODS: Thirty-two CHF patients (functional class: 17 in NYHA II and 15 in NYHA III at the time of this study) were compared with 18 normal control subjects. Myocardial scintigraphy was performed 15 min and 3 hours after I-123 BMIPP injection. The heart-to-mediastinum count ratio of I-123 BMIPP on the initial (H/Mi) and delayed (H/Md) images and the washout rate (WR) were calculated. RESULTS: Both H/Mi and H/Md were lower in CHF than in controls (H/Mi 1.96+/-0.18 vs. 2.30+/-0.29; H/Md 1.72+/-0.15 vs. 1.97+/-0.21; both P<0.001), but WR was higher in CHF than in controls (WR (%) 23.7+/-5.7 vs. 18.2+/-6.0, P<0.01). Both H/Mi (R = 0.42, P<0.05) and H/Md (R = 0.45, P<0.05) correlated positively with the left ventricular (LV) ejection fraction (EF), estimated by echocardiography. The WR correlated positively with the plasma B-type natriuretic peptide (BNP) level (R = 0.47, P<0.01). Kaplan-Meier analysis showed an earlier CHF progression for patients with a lower H/Mi (<1.94). CONCLUSION: Myocardial metabolic abnormality evaluated by I-123 BMIPP scintigraphy is related to the severity of CHF. Furthermore, it may be useful as a predictor for cardiac events.
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Authors | I Nakae, S Matsuo, T Koh, K Mitsunami, M Horie |
Journal | Acta radiologica (Stockholm, Sweden : 1987)
(Acta Radiol)
Vol. 47
Issue 8
Pg. 810-6
(Oct 2006)
ISSN: 0284-1851 [Print] England |
PMID | 17050361
(Publication Type: Journal Article)
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Chemical References |
- Fatty Acids
- Iodine Radioisotopes
- Iodobenzenes
- Radiopharmaceuticals
- iodofiltic acid
- Natriuretic Peptide, Brain
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Fatty Acids
- Female
- Heart Failure
(diagnostic imaging)
- Humans
- Iodine Radioisotopes
- Iodobenzenes
- Male
- Middle Aged
- Natriuretic Peptide, Brain
(blood)
- Radionuclide Imaging
- Radiopharmaceuticals
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