Low-dose, long-term caroverine administration attenuates impulse noise-induced hearing loss in the rat.

Abstract

CONCLUSION:

Physiological and morphological assessments indicated that low-dose and long-term caroverine delivery might be a new approach to protect against impulse noise-induced hearing loss.

BACKGROUND:

Although the exact mechanisms by which impulse noise causes hearing loss are still unclear, there is accumulating evidence that increased reactive oxygen species (ROS) production and excessive glutamate released from the inner hair cells lead to hair cell loss and consequently hearing loss. Caroverine is an antagonist of two glutamate receptors, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors in the inner ear, as well as an antioxidant.

MATERIALS AND METHODS:

In this study, caroverine was delivered subcutaneously using an osmotic pump. This kind of delivery has the advantage, via continuous, long-term and low dose drug administration, of avoiding systemic side effects.

RESULTS:

It was shown that caroverine could significantly protect the cochlea against impulse noise trauma.

• Authors: Maoli Duan, Zhiqiang Chen, Jianxin Qiu, Mats Ulfendahl, Göran Laurell, Erik Borg, Runsheng Ruan
• Journal: Acta oto-laryngologica (Acta Otolaryngol) Vol. 126 Issue 11 Pg. 1140-7 (Dec 2006) ISSN: 0001-6489 [Print] England
• PMID: 17050305 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antioxidants
• Quinoxalines
• Reactive Oxygen Species
• Receptors, AMPA
• Receptors, N-Methyl-D-Aspartate
• caroverine

Topics

• Animals
• Antioxidants (pharmacology)
• Auditory Fatigue (drug effects, physiology)
• Brain Stem (drug effects, pathology, physiopathology)
• Dose-Response Relationship, Drug
• Evoked Potentials, Auditory, Brain Stem (drug effects, physiology)
• Hair Cells, Auditory, Inner (drug effects, pathology, physiopathology)
• Hair Cells, Auditory, Outer (drug effects, pathology, physiopathology)
• Hearing Loss, Noise-Induced (pathology, physiopathology, prevention & control)
• Injections, Subcutaneous
• Quinoxalines (pharmacology)
• Rats
• Rats, Sprague-Dawley
• Reactive Oxygen Species (metabolism)
• Receptors, AMPA (antagonists & inhibitors, physiology)
• Receptors, N-Methyl-D-Aspartate (antagonists & inhibitors, physiology)