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Enhanced immune responses induced by vaccine using Sendai virosomes as carrier.

Abstract
Sendai virosomes can deliver encapsulated contents into the cytoplasm directly in a virus fusion-dependent manner. In this paper, Sendai virosomes-formulated melanoma vaccine was constructed and its anti-tumor effects were investigated. The melanoma vaccine was prepared by encapsulating mixture antigen into the Sendai virosomes. The antigen, mixture proteins were extracted from B(16) melanoma cells. The cytotoxic T lymphocyte (CTL) response level was evaluated by (51)Cr release method, and the change of CD4(+) and CD8(+) expression as well as the concentration of IgG in serum of immunized mice was measured. The results showed that Sendai virosomes-formulated melanoma vaccine can effectively elicit not only systemic immune response but also strong CTL response. Sendai virosomes can be used as an effective vector for use in anti-tumor vaccine therapy.
AuthorsQiang Li, Jian-Qing Gao, Li-Yan Qiu, Fu-De Cui, Yi Jin
JournalInternational journal of pharmaceutics (Int J Pharm) Vol. 329 Issue 1-2 Pg. 117-21 (Feb 01 2007) ISSN: 0378-5173 [Print] Netherlands
PMID17046184 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Cancer Vaccines
  • Virosomes
Topics
  • Animals
  • Cancer Vaccines (administration & dosage, immunology, therapeutic use)
  • Drug Delivery Systems
  • Female
  • Melanoma, Experimental (drug therapy, immunology)
  • Mice
  • Mice, Inbred C57BL
  • Sendai virus (immunology)
  • Virosomes (administration & dosage, immunology)

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