Abstract |
To investigate the association between polymorphisms in the G protein-coupled receptor kinase 4 gene (GRK4) (R65L, A142V and A486V) and essential hypertension in northern Han Chinese, we conducted a case-control study consisting of 503 individuals with essential hypertension (HT) and 490 age-, gender-, and area-matched normotensive (NT) controls. The three GRK4 variants were genotyped by PCR-RFLP analysis. Both haplotype and single locus analysis were used to process the genotyping data. The A486 allele showed a significant association with HT (P < 0.001). A total of 6 haplotypes were observed in the entire population, with the haplotypes L-V-A and R-A-A being found to be significantly related to hypertension (P= 0.001).
|
Authors | Yaping Wang, Biao Li, Weiyan Zhao, Pei Liu, Qi Zhao, Shufeng Chen, Hongfan Li, Dongfeng Gu |
Journal | Annals of human genetics
(Ann Hum Genet)
Vol. 70
Issue Pt 6
Pg. 778-83
(Nov 2006)
ISSN: 0003-4800 [Print] England |
PMID | 17044852
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Protein Serine-Threonine Kinases
- G-Protein-Coupled Receptor Kinase 4
- GRK4 protein, human
|
Topics |
- Aged
- Alleles
- Case-Control Studies
- China
(epidemiology)
- Female
- G-Protein-Coupled Receptor Kinase 4
- Genetic Variation
- Haplotypes
- Humans
- Hypertension
(epidemiology, genetics)
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
- Protein Serine-Threonine Kinases
(genetics)
|