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Association study of G protein-coupled receptor kinase 4 gene variants with essential hypertension in northern Han Chinese.

Abstract
To investigate the association between polymorphisms in the G protein-coupled receptor kinase 4 gene (GRK4) (R65L, A142V and A486V) and essential hypertension in northern Han Chinese, we conducted a case-control study consisting of 503 individuals with essential hypertension (HT) and 490 age-, gender-, and area-matched normotensive (NT) controls. The three GRK4 variants were genotyped by PCR-RFLP analysis. Both haplotype and single locus analysis were used to process the genotyping data. The A486 allele showed a significant association with HT (P < 0.001). A total of 6 haplotypes were observed in the entire population, with the haplotypes L-V-A and R-A-A being found to be significantly related to hypertension (P= 0.001).
AuthorsYaping Wang, Biao Li, Weiyan Zhao, Pei Liu, Qi Zhao, Shufeng Chen, Hongfan Li, Dongfeng Gu
JournalAnnals of human genetics (Ann Hum Genet) Vol. 70 Issue Pt 6 Pg. 778-83 (Nov 2006) ISSN: 0003-4800 [Print] England
PMID17044852 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Protein Serine-Threonine Kinases
  • G-Protein-Coupled Receptor Kinase 4
  • GRK4 protein, human
Topics
  • Aged
  • Alleles
  • Case-Control Studies
  • China (epidemiology)
  • Female
  • G-Protein-Coupled Receptor Kinase 4
  • Genetic Variation
  • Haplotypes
  • Humans
  • Hypertension (epidemiology, genetics)
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Protein Serine-Threonine Kinases (genetics)

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