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Antisynthetase syndrome associated with sarcoidosis.

Abstract
A 30-year-old man complained of polyarthralgia and fatigue. The clinical findings and laboratory data included myositis, polyarthritis, interstitial pneumonia, Raynaud's phenomenon, mechanic's hand, and anti PL-7 antibody (threonyl-tRNA synthetase antibody). All of these signs were consistent with antisynthetase syndrome. His chest radiograph revealed bilateral hilar lymphadenopathy. Biopsy specimens from his mediastinal lymph node and muscle showed noncaseating epithelioid cell granulomas. Lung histology revealed nonspecific interstitial pneumonia. Antisynthetase syndrome associated with sarcoidosis was diagnosed. Interstitial pneumonia in this patient responded well to high-dose corticosteroid therapy.
AuthorsYu Asanuma, Reiko Koichihara, Shinichiro Koyama, Yoshinori Kawabata, Shio Kobayashi, Tsuneyo Mimori, Masato Moriguchi
JournalInternal medicine (Tokyo, Japan) (Intern Med) Vol. 45 Issue 18 Pg. 1065-8 ( 2006) ISSN: 1349-7235 [Electronic] Japan
PMID17043379 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Autoantibodies
  • Glucocorticoids
  • Prednisolone
  • Ligases
Topics
  • Adult
  • Autoantibodies (immunology)
  • Autoimmune Diseases (complications, drug therapy, immunology)
  • Glucocorticoids (therapeutic use)
  • Humans
  • Ligases (immunology)
  • Male
  • Prednisolone (therapeutic use)
  • Sarcoidosis (complications, drug therapy, pathology)
  • Smoking
  • Syndrome

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