Abstract | HYPOTHESIS: Accurate differentiation between inflammatory and neoplastic tumors of the pancreas remains a diagnostic dilemma for surgeons. The aim of the study was to assess the utility of 2 neoplastic markers, cancer antigen (CA) 19-9 and CA 125, in the differential diagnosis of pancreatic tumors. DESIGN: The patients were assigned to a malignant or benign group based on cytological and histological evaluation of pancreatic lesion samples. The serum from each patient was tested for CA 19-9 and CA 125. SETTING AND PATIENTS: One hundred ten patients with heterogeneous pancreatic lesions (inflammatory and malignant tumors) treated at a surgical department of a university hospital were analyzed. INTERVENTIONS: Samples for cytological and histological evaluation were taken during ultrasonography-guided fine-needle aspiration biopsy or open surgery. MAIN OUTCOME MEASURES: Sensitivity, specificity, and positive and negative predictive values of each test in the differential diagnosis of pancreatic tumors were determined. RESULTS: The sensitivity, specificity, positive predictive value, and negative predictive value of the CA 19-9 test were 80.8%, 89.1%, 93.7%, and 89.2%, respectively. The sensitivity, specificity, positive predictive value, and negative predictive value of the CA 125 test were 60.8%, 83.3%, 88.2%, and 50.8%, respectively. The sensitivity and specificity of a combined evaluation of both CA 19-9 and CA 125 tests were 87.8% and 77.8%, respectively. CONCLUSIONS: Taking into account the high but still limited sensitivity and specificity of the CA 19-9 and CA 125 tests, their results in the differential diagnosis of pancreatic tumors should be interpreted consistently and in reference to imaging techniques such as ultrasonography and computed tomography.
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Authors | Grzegorz Cwik, Grzegorz Wallner, Tomasz Skoczylas, Aleksander Ciechanski, Krzysztof Zinkiewicz |
Journal | Archives of surgery (Chicago, Ill. : 1960)
(Arch Surg)
Vol. 141
Issue 10
Pg. 968-73; discussion 974
(Oct 2006)
ISSN: 0004-0010 [Print] United States |
PMID | 17043274
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- CA-125 Antigen
- CA-19-9 Antigen
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Topics |
- Adult
- Aged
- Biomarkers, Tumor
(blood)
- Biopsy, Fine-Needle
- CA-125 Antigen
(blood)
- CA-19-9 Antigen
(blood)
- Diagnosis, Differential
- Humans
- Male
- Middle Aged
- Pancreatic Neoplasms
(blood, diagnosis, pathology)
- Sensitivity and Specificity
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