A comparison of the in vitro cytotoxicity of daunorubicin and liposomal daunorubicin in pediatric acute leukemia.

Abstract	Anthracyclines are effective in the treatment of leukemia, but their use is limited because of cardiotoxicity. Liposomal daunorubicin (L-DNR) is potentially less cardiotoxic than daunorubicin (DNR). We compared in vitro cytotoxicity in pediatric acute leukemia samples and found no significant differences between cytotoxicity of DNR and L-DNR.
Authors	Bianca F Goemans, Christian M Zwaan, Dirk Reinhardt, Brenda E S Gibson, K Hählen, Gert Jan L Kaspers
Journal	Haematologica (Haematologica) Vol. 91 Issue 11 Pg. 1573-4 (Nov 2006) ISSN: 1592-8721 [Electronic] Italy
PMID	17043024 (Publication Type: Comparative Study, Letter)
Chemical References	Liposomes Daunorubicin
Topics	Adolescent Child Child, Preschool Daunorubicin (administration & dosage, adverse effects) Female Humans Leukemia, Myeloid, Acute (drug therapy, pathology) Liposomes (administration & dosage) Male

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