The aim of this study was to compare clinical outcome of a
stainless-steel stent coated with
titanium nitride oxide (TITANOX) and a
paclitaxel-eluting
stent (PES) in routine clinical practice represented by two prospective registries including all patients with de novo
coronary artery disease treated exclusively with a TITANOX
stent (n = 201) or with a PES (n = 204) between May 2003 and November 2004 (63% of all PCI patients). The primary endpoint of the study was
major adverse cardiac events (
MACE) at 30 days and 12 months. The TITANOX
stent patients were more frequently (p = 0.011) treated for acute
myocardial infarction and had more complex B- and C-type lesions (p = 0.004). The PES patients had longer (p < 0.001) total
stent length. At 30 days, the rate of
MACE was 0% and 4.9% for the TITANOX
stent and PES groups, respectively (p = 0.001). A significant difference in target vessel revascularization (TVR) was seen in favor of the TITANOX
stent (0% vs. 2.9% for PES; p = 0.014). This was mainly driven by
stent thrombosis (n = 7). At 12 months, the difference in
MACE was no longer significant (10.9% vs. 13.7%; p = 0.40), but the rate of
myocardial infarction was lower in the TITANOX
stent group (4.5% vs. 10.3%; p = 0.025). The rate of TVR (8% vs. 6.9%; p = 0.67) was similar between the two groups. In conclusion, both the TITANOX-coated
stent and PES resulted in good clinical outcome with infrequent need for repeat interventions in the real-world setting of high-risk patients and complex coronary lesions.