Scleroderma renal crisis in a patient with anticentromere antibody-positive limited cutaneous systemic sclerosis.

Abstract

We have encountered a 68-year-old Japanese woman with limited cutaneous systemic sclerosis who developed de novo onset of accelerated hypertension and renal dysfunction; thus we diagnosed scleroderma renal crisis. Anticentromere antibody alone was identified, and not anti-DNA topoisomerase I antibody, anti-RNA polymerase antibodies, anti-Th/To antibodies, or antiribonucleoprotein antibodies, even with use of immunoprecipitation assay. She was successfully treated with angiotensin-converting enzyme inhibitor. This case, scleroderma renal crisis with detection of anticentromere antibody, is thought to be extremely uncommon.

• Authors: Toshiro Sugimoto, Mariko Soumura, Kiichiro Danno, Kenzo Kaji, Miki Kondo, Kunio Hirata, Jun Nakazawa, Takashi Uzu, Yoshihiko Nishio, Atsunori Kashiwagi
• Journal: Modern rheumatology (Mod Rheumatol) Vol. 16 Issue 5 Pg. 309-11 ( 2006) ISSN: 1439-7595 [Print] England
• PMID: 17039313 (Publication Type: Case Reports, Journal Article)

Chemical References

• Angiotensin-Converting Enzyme Inhibitors
• Autoantibodies
• Autoantigens

Topics

• Aged
• Angiotensin-Converting Enzyme Inhibitors (therapeutic use)
• Autoantibodies (blood)
• Autoantigens (immunology)
• Centromere (immunology)
• Esophagitis, Peptic (complications)
• Female
• Humans
• Hypertension (etiology)
• Kidney Diseases (etiology)
• Liver Cirrhosis, Biliary (complications)
• Pruritus (complications)
• Raynaud Disease (complications)
• Scleroderma, Limited (complications, immunology, physiopathology)