| Abstract | PURPOSE: To determine the long-term overall survival of male patients with stage II node positive breast cancer treated with adjuvant chemotherapy. PATIENTS AND METHODS: Between 1974 and 1988, 31 male breast cancer patients were prospectively enrolled on study MB-82 in the National Cancer Institute. Following mastectomy, patients were treated with 12 cycles of cyclophosphamide, methotrexate, and fluorouracil (CMF) chemotherapy. RESULTS: Median patient age was 61 years (38-74 years). Twenty-one patients (68%) had 1-3 positive axillary lymph nodes while ten patients (32%) had four or more positive nodes. Estrogen receptor status was positive in 22 (71%), negative in 1 (3%), and unknown in 8 (26%) tumors. Progesterone receptor status was positive in 18 (58%), negative in 3 (10%), and unknown in 10 (32%) tumors. Median potential follow-up for all patients is 22.5 years with a median survival of 16.3 years. Twenty-one of 31 patients have died; one from a treatment-related complication, nine patients from recurrent breast cancer, five from other cancers, one from non-cancer related causes, and five from unknown causes. Ten patients remain alive at a median of 19.2 years. The overall survival probability at 10 years is 64.5% (95% CI: 46.9-78.9%), at 15 years is 51.6% (95% CI: 34.8-68%), and at 20 years is 42.4% (95% CI: 25.8-60.8%). CONCLUSION: To our knowledge, 20-year prospective data with adjuvant chemotherapy in male breast cancer has never been reported. Adjuvant chemotherapy may benefit male breast cancer patients with positive nodes. |
| Authors | Janice M Walshe, Arlene W Berman, Ujala Vatas, Seth M Steinberg, William F Anderson, Marc E Lippman, Sandra M Swain
(Affiliation: Breast Cancer Section, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20889, USA.)
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| Journal | Breast cancer research and treatment
(Breast Cancer Res Treat)
Vol. 103
Issue 2
Pg. 177-83
(Jun 2007)
ISSN: 0167-6806 Netherlands |
| PMID | 17039267
(Publication Type: Journal Article, Research Support, N.I.H., Intramural)
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| Chemical References |
- CMF regimen
- Cyclophosphamide
- Fluorouracil
- Methotrexate
|
| Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage, therapeutic use)
- Breast Neoplasms, Male
(drug therapy, mortality, pathology)
- Chemotherapy, Adjuvant
- Cyclophosphamide
(administration & dosage)
- Fluorouracil
(administration & dosage)
- Follow-Up Studies
- Humans
- Lymphatic Metastasis
- Male
- Methotrexate
(administration & dosage)
- Middle Aged
- Neoplasm Recurrence, Local
- Prospective Studies
- SEER Program
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