Abstract |
The red cell preservation solution PAGGS- Mannitol differs from the well documented PAGGS- Sorbitol only by the exchange from Sorbitol in Mannitol. In a clinical investigation with volunteers, up to 21 of the pure PAGGS- Mannitol solution were infused within 4 h. Blood and urine parameters were determined. The solution was well tolerated, no unexpected change of blood and urine parameters was found. The 24 h red cell in vivo survival rate of PAGGS- Mannitol was found to be 74.5 +/- 4.4%, after 49 days storage, a value which was described for PAGGS- Sorbitol before. In vitro data on storage of red cell concentrates with and without buffy coat were determined for hemolysis, 2,3-DPG and ATP using a blood bag system with DEHP and TOTM plastisized PVC. If 1% hemolysis is regarded as acceptable, red cell concentrates can be stored in PAGGS- Mannitol with a TOTM plastisized blood bag system up to 42 days. Under these conditions the amount of plastisizer in the red cell concentrate was found to be only 1% of the amount determined in a standard DEHP plastisized PVC blood bag system.
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Authors | W H Walker, M Netz, K H Gänshirt |
Journal | Beitrage zur Infusionstherapie = Contributions to infusion therapy
(Beitr Infusionsther)
Vol. 26
Pg. 55-9
( 1990)
ISSN: 1011-6974 [Print] Switzerland |
Vernacular Title | 49 Tage Lagerung von Erythrozytenkonzentraten in Blutbeuteln mit der Konservierungslösung PAGGS-Mannitol. |
PMID | 1703901
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- PAGGS-sorbitol solution
- Phosphates
- Guanosine
- Mannitol
- Sodium Chloride
- Sorbitol
- Glucose
- Adenine
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Topics |
- Adenine
(administration & dosage)
- Blood Preservation
(instrumentation, methods)
- Blood Transfusion
(instrumentation, methods)
- Erythrocyte Aging
(drug effects)
- Erythrocyte Transfusion
- Glucose
(administration & dosage)
- Guanosine
(administration & dosage)
- Hemolysis
(drug effects)
- Humans
- Mannitol
(administration & dosage)
- Phosphates
(administration & dosage)
- Sodium Chloride
(administration & dosage)
- Sorbitol
(administration & dosage)
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