Abstract |
Annual leishmanin skin test (LST) surveys were conducted in a visceral leishmaniasis-endemic Bangladeshi community from 2002 through 2004, using Leishmania infantum antigen from the same manufacturer and batch. In 2002, 530 (35%) of 1,532 had positive LST results; the prevalence increased with increasing age. The LST result was positive in 24 (51%) of 47, 18 (72%) of 25, and 11 (85%) of 13 kala-azar patients treated in the previous 1-11, 12-23, and 24-35 months. A positive LST result in 2002 was associated with protection against subsequent kala-azar (P < 0.0001). In 2003-2004, decreased antigen sensitivity was observed. Among 686 participants, 34% were LST-positive in 2002, 29% in 2003, and 19% in 2004. Of 63 cured kala-azar patients, 70% were positive in 2002, 53% in 2003, and only 30% in 2004. Among 171 participants tested with both antigens, L. infantum study antigen sensitivity was 70% compared with L. amazonensis antigen. Our data underscore the need for better production, standardization, and documentation of sensitivity, potency, and stability of leishmanin antigens.
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Authors | Caryn Bern, Josef Amann, Rashidul Haque, Rajib Chowdhury, Mustakim Ali, Katie M Kurkjian, Louise Vaz, Yukiko Wagatsuma, Robert F Breiman, W Evan Secor, James H Maguire |
Journal | The American journal of tropical medicine and hygiene
(Am J Trop Med Hyg)
Vol. 75
Issue 4
Pg. 744-8
(Oct 2006)
ISSN: 0002-9637 [Print] United States |
PMID | 17038705
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antigens, Protozoan
- leishmanin
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Topics |
- Adolescent
- Adult
- Animals
- Antigens, Protozoan
(immunology)
- Bangladesh
(epidemiology)
- Child
- Child, Preschool
- Humans
- Leishmania infantum
(immunology)
- Leishmania mexicana
(immunology)
- Leishmaniasis, Visceral
(diagnosis, epidemiology, immunology)
- Longitudinal Studies
- Middle Aged
- Sensitivity and Specificity
- Skin Tests
(standards)
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