Abstract | OBJECTIVE: METHODS:
Diabetic nephropathy was induced in Sprague-Dalwley rats by intraperitoneal injection of STZ, while the rats of normal group were injected with normal saline. Biochemical indices of blood and urine specimens were observed in both groups at weeks 2, 4 and 6 respectively. The renal expression levels of Cubilin in the two groups were determined by immunohistochemistry and RT-PCR. RESULTS: The expression level of Cubilin in the diabetic nephropathy group was significantly decreased at week 2 after operation (P < 0.05), and it continued to decrease from week 2 to week 6. Also there was significant difference between each two time-points (P < 0.05), and the Cubilin expression level was negatively correlated with albuminuria (P < 0.01). CONCLUSION:
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Authors | Mei Feng, Zhu Zhang, Ping Fu, Song-min Huang, Yi-bin Yang, Ke-liang Su, Ze-jun Chen, Wan-xin Tang |
Journal | Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
(Sichuan Da Xue Xue Bao Yi Xue Ban)
Vol. 37
Issue 5
Pg. 738-41
(Sep 2006)
ISSN: 1672-173X [Print] China |
PMID | 17037740
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Biomarkers
- Receptors, Cell Surface
- intrinsic factor-cobalamin receptor
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Topics |
- Albuminuria
(metabolism)
- Animals
- Biomarkers
- Diabetes Mellitus, Experimental
(metabolism)
- Diabetic Nephropathies
(metabolism)
- Male
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Receptors, Cell Surface
(biosynthesis, genetics)
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