| Abstract | AIMS AND BACKGROUND: Phyllodes tumor of the breast with osteosarcomatous differentiation is rare and very little is known about its molecular profile. METHODS AND STUDY DESIGN: An immunohistochemical panel with 37 primary antibodies including cytokeratins, mesenchymal markers, key regulators of the cell cycle, oncogenes, apoptosis-related proteins, metalloproteinases and their inhibitors was performed on a formalin-fixed paraffin-embedded sample of phyllodes tumor with osteosarcomatous differentiation in a 49-year-old woman. RESULTS: Antiapoptotic stimuli (survivin) predominated in sarcomatous cells. Antiproteolytic stimuli (TIMP-1, TIMP-2 and PAI) were preponderant in all cells, a surprising fact in view of the aggressiveness of the neoplasm. The immunoprofile of the osteoblastic and stromal cells was quite similar, except for c-erbB-3, c-myc, cyclin D1 and p21. Both exhibited positive cells for actin, MyoD1 and GFAP. CONCLUSIONS: Our results suggest that this osteosarcoma may have originated from metaplasia of stromal cells that underwent a malignant change. |
| Authors | Alfredo Ribeiro-Silva, Leandra Náira Zambelli Ramalho, Sérgio Zucoloto
(Affiliation: Department of Pathology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirdo Preto, SP, Brazil. arsilva at fmrp.usp.br)
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| Journal | Tumori
(Tumori)
2006 Jul-Aug
Vol. 92
Issue 4
Pg. 340-6
ISSN: 0300-8916 Italy |
| PMID | 17036527
(Publication Type: Case Reports, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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| Chemical References |
- Tumor Markers, Biological
|
| Topics |
- Axilla
- Breast Neoplasms
(chemistry, pathology, surgery)
- Cell Transformation, Neoplastic
(chemistry)
- Epithelial Cells
(chemistry, pathology)
- Fatal Outcome
- Female
- Humans
- Immunohistochemistry
- Lymph Node Excision
- Mastectomy, Modified Radical
- Mesenchymal Stem Cells
(chemistry, pathology)
- Middle Aged
- Osteosarcoma
(chemistry, pathology, surgery)
- Phyllodes Tumor
(chemistry, pathology, surgery)
- Tumor Markers, Biological
(analysis, immunology)
|
