HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Enhancement of nonspecific resistance to microbial infections of synthetic lipid A-subunit analogues of GLA-27 modified at the C1 position of the glucosamine backbone.

Abstract
The C1 position of lipid A-subunit analogue GLA-27, 4-O-phosphono-D-glucosamine carrying N-3-tetradecanoyloxytetradecanoyl(C14-O-(C14)) and 3-O-tetradecanoyl (C14) groups, was S-acetylated, thiolated or phosphorylated. Enhancement of nonspecific resistance to Pseudomonas aeruginosa and vaccinia virus infections of these chemically modified compounds were investigated. Thiolation augmented the nonspecific resistance to P. aeruginosa infection. Protective activity against vaccinia virus infection was reduced by all the chemical modifications. NK cell activity was found not to be effected by S-acetylation, but to be decreased slightly by thiolation or phosphorylation. IFN-inducing activity was reduced remarkably by thiolation or S-acetylation, or completely diminished by phosphorylation, compared with that of GLA-27.
AuthorsM Nakatsuka, S Ikeda, Y Kumazawa, M Matsuura, C Nishimura, J Y Homma, M Kiso, A Hasegawa
JournalInternational journal of immunopharmacology (Int J Immunopharmacol) Vol. 12 Issue 6 Pg. 599-603 ( 1990) ISSN: 0192-0561 [Print] ENGLAND
PMID1703131 (Publication Type: Journal Article)
Chemical References
  • Lipid A
  • GLA 27
  • Interferons
Topics
  • Animals
  • Female
  • Immunity, Innate (drug effects)
  • Interferons (biosynthesis)
  • Killer Cells, Natural (immunology)
  • Lipid A (analogs & derivatives, pharmacology)
  • Mice
  • Mice, Inbred ICR
  • Pseudomonas Infections (immunology)
  • Structure-Activity Relationship
  • Vaccinia (immunology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: