Fibrinolytic effect of a particular glycosaminoglycan (endoglycan) per os on normals and in patients with chronic artery disease.

Abstract

Endoglycan, a heparan-dermatan sulphate association, is a highly purified heparinoid extracted from porcine intestinal mucosa. The aim of our study was to investigate the fibrinolytic system in a group of healthy controls and vascular disease patients, before and after endoglycan administration "per os". All the patients had a reduced basal fibrinolytic activity. The tests carried out were PT, PTT, FDP, Euglobulin Lysis Time (ELT), fibrinogen, plasminogen, alpha 2-antiplasmin, alpha 2-macroglobulin and t-PA activity assayed with a chromogenic method. After endoglycan administration, we have shown a significant shortening of ELT with complete normalization during the treatment. A fibrinogen decrease and either plasminogen or alpha 2-antiplasmin increase was seen. This was shown in normals too, however to a lesser extent. During therapy most of the healthy subjects, but only some patients, showed increased t-PA levels. Before and during treatment, significantly higher t-PA levels were seen in the control group as compared to the patients group. Reduced t-PA release was seen in our vascular disease patients. In conclusion, endoglycan "per os" appears to exert a stimulatory effect on the fibrinolytic system.

• Authors: G M Patrassi, A Veronesi, M T Sartori, M L Viero, G Boeri, A Girolami
• Journal: Folia haematologica (Leipzig, Germany : 1928) (Folia Haematol Int Mag Klin Morphol Blutforsch) Vol. 117 Issue 3 Pg. 369-76 ( 1990) ISSN: 0323-4347 [Print] Germany
• PMID: 1703105 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Fibrin Fibrinogen Degradation Products
• Fibrinolytic Agents
• alpha-Macroglobulins
• plasmin-alpha(2)-macroglobulin complex
• Dermatan Sulfate
• Fibrinogen
• Plasminogen
• Heparin
• Tissue Plasminogen Activator
• Fibrinolysin

Topics

• Adult
• Arteriosclerosis (blood, drug therapy)
• Blood Coagulation Tests
• Dermatan Sulfate (therapeutic use)
• Female
• Fibrin Fibrinogen Degradation Products (metabolism)
• Fibrinogen (metabolism)
• Fibrinolysin (metabolism)
• Fibrinolytic Agents (therapeutic use)
• Heparin (therapeutic use)
• Humans
• Kinetics
• Male
• Middle Aged
• Plasminogen (metabolism)
• Reference Values
• Tissue Plasminogen Activator (blood)
• alpha-Macroglobulins (metabolism)