Abstract | BACKGROUND & AIMS: METHODS: RESULTS: Clinical data were comparable between groups. The probability of developing proved or possible infections, proved infections, and spontaneous bacteremia or spontaneous bacterial peritonitis was significantly higher in patients receiving norfloxacin (33% vs 11%, P = .003; 26% vs 11%, P = .03; and 12% vs 2%, P = .03, respectively). The type of antibiotic used ( norfloxacin), transfusion requirements at inclusion, and failure to control bleeding were independent predictors of infection. Seven gram-negative bacilli were isolated in the norfloxacin group, and 6 were quinolone resistant. Non-enterococcal streptococci were only isolated in the norfloxacin group. No difference in hospital mortality was observed between groups. CONCLUSIONS:
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Authors | Javier Fernández, Luis Ruiz del Arbol, Cristina Gómez, Rosa Durandez, Regina Serradilla, Carlos Guarner, Ramón Planas, Vicente Arroyo, Miguel Navasa |
Journal | Gastroenterology
(Gastroenterology)
Vol. 131
Issue 4
Pg. 1049-56; quiz 1285
(Oct 2006)
ISSN: 0016-5085 [Print] United States |
PMID | 17030175
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Anti-Infective Agents
- Ceftriaxone
- Norfloxacin
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Topics |
- Administration, Oral
- Aged
- Anti-Bacterial Agents
(administration & dosage)
- Anti-Infective Agents
(administration & dosage)
- Antibiotic Prophylaxis
- Bacteremia
(mortality, prevention & control)
- Bacterial Infections
(mortality, prevention & control)
- Ceftriaxone
(administration & dosage)
- Female
- Gastrointestinal Hemorrhage
(drug therapy, etiology, mortality)
- Humans
- Injections, Intravenous
- Liver Cirrhosis
(complications, drug therapy, mortality)
- Male
- Middle Aged
- Norfloxacin
(administration & dosage)
- Peritonitis
(mortality, prevention & control)
- Risk Factors
- Treatment Outcome
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