Voltage-gated potassium channel antibodies associated limbic encephalitis in a patient with invasive thymoma.

Abstract

Recently, limbic encephalitis (LE) associated with Voltage-gated potassium channel antibody (VGKC-Ab) has been postulated as a new autoimmune disorder. Most previously reported cases of VGKC-Ab-associated LE were non-paraneoplastic, and reports of a paraneoplastic type are rare. Here we describe a 59-year-old woman with paraneoplastic VGKC-Ab-associated LE preceding the recurrence of invasive thymoma. There was a close temporal relationship between the clinical course and the changes of the VGKC-Ab titer. Unlike many of the non-paraneoplastic VGKC-Ab-associated LE cases, our cases showed the more extensive high intensity lesions on MRI and the absence of seizure and hyponatremia.

• Authors: Tomohiko Ohshita, Hideshi Kawakami, Hirofumi Maruyama, Tatsuo Kohriyama, Kimiyoshi Arimura, Masayasu Matsumoto
• Journal: Journal of the neurological sciences (J Neurol Sci) Vol. 250 Issue 1-2 Pg. 167-9 (Dec 01 2006) ISSN: 0022-510X [Print] Netherlands
• PMID: 17028029 (Publication Type: Case Reports, Journal Article)

Chemical References

• Autoantibodies
• Potassium Channels, Voltage-Gated

Topics

• Autoantibodies (immunology)
• Disease Progression
• Female
• Gyrus Cinguli (immunology, pathology, physiopathology)
• Hippocampus (immunology, pathology, physiopathology)
• Humans
• Hyponatremia (etiology, physiopathology)
• Limbic Encephalitis (immunology, metabolism, physiopathology)
• Limbic System (immunology, pathology, physiopathology)
• Magnetic Resonance Imaging
• Middle Aged
• Neoplasm Invasiveness (immunology)
• Neoplasm Recurrence, Local (complications, immunology, physiopathology)
• Potassium Channels, Voltage-Gated (immunology)
• Prefrontal Cortex (immunology, pathology, physiopathology)
• Seizures (etiology, physiopathology)
• Thymoma (complications, immunology, physiopathology)