Clinicopathological significance of stromal variables: angiogenesis, lymphangiogenesis, inflammatory infiltration, MMP and PINCH in colorectal carcinomas.

Abstract	Cancer research has mainly focused on alterations of genes and proteins in cancer cells themselves that result in either gain-of-function in oncogenes or loss-of-function in tumour-suppressor genes. However, stromal variables within or around tumours, including blood and lymph vessels, stromal cells and various proteins, have also important impacts on tumour development and progression. It has been shown that disruption of stromal-epithelial interactions influences cellular proliferation, differentiation, death, motility, genomic integrity, angiogenesis, and other phenotypes in various tissues. Moreover, stromal variables are also critical to therapy in cancer patients. In this review, we mainly focus on the clinicopathological significance of stromal variables including angiogenesis, lymphangiogenesis, inflammatory infiltration, matrix metalloproteinase (MMP), and the particularly interesting new cysteine-histidine rich protein (PINCH) in colorectal cancer (CRC).
Authors	Xiao-Feng Sun, Hong Zhang
Journal	Molecular cancer (Mol Cancer) Vol. 5 Pg. 43 (Oct 06 2006) ISSN: 1476-4598 [Electronic] England
PMID	17026740 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References	Adaptor Proteins, Signal Transducing DNA-Binding Proteins Enzyme Inhibitors LIM Domain Proteins LIMS1 protein, human Matrix Metalloproteinase Inhibitors Membrane Proteins Matrix Metalloproteinases
Topics	Adaptor Proteins, Signal Transducing Adenocarcinoma (drug therapy, etiology, metabolism) Colorectal Neoplasms (drug therapy, etiology, metabolism) DNA-Binding Proteins (metabolism, physiology) Enzyme Inhibitors (therapeutic use) Humans Inflammation (etiology, pathology) LIM Domain Proteins Lymphangiogenesis (physiology) Matrix Metalloproteinase Inhibitors Matrix Metalloproteinases (metabolism, physiology) Membrane Proteins Models, Biological Neoplasm Invasiveness (pathology) Neovascularization, Pathologic (etiology) Stromal Cells (pathology, physiology)

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