Obesity risk associated with the K121Q polymorphism of the glycoprotein PC-1 gene.

Abstract

BACKGROUND:

Obesity is considered to be a multifactorial trait resulting from the combined influence of genetic and environmental determinants. Insulin resistance plays an important role in the development of obesity. Plasma-cell membrane differentiation antigene-1 (PC-1) inhibits insulin receptor signalling when overexpressed and thus causes insulin resistance. PC-1 gene polymorphism might be associated with adipocyte metabolism disturbance and energy imbalance. The purpose of this study was to determine whether K121Q polymorphism in PC-1 gene is involved in obesity susceptibility in Chinese Han population.

METHODS:

The genotype of the polymorphism was determined using polymerase chain reaction-restriction fragment length polymorphism analysis for 338 unrelated subjects of Beijing, China. Their Body mass index (BMI), plasma glucose, total cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL), free fatty acid (FFA) and insulin level were measured. Chi-square analyses were applied to test the significance differences in genotypic and allelic frequencies. Association studies were undertaken using the t-test and logistic regression analyses.

RESULTS:

The obese had significantly higher frequency of KQ/QQ genotype or Q allele than non-obese in females (26.7% vs. 10.9%, p = 0.014 and 13.3% vs. 5.5%, p = 0.021). Significant elevation of insulin amongst the Q121 carrier women in obesity individuals and higher FFA level of Q121 carrier men in non-obese controls (BMI < or = 23 kg/m2) were observed. Binary logistic regression analysis revealed that PC-1 genotype together with higher glucose, total cholesterol, triglyceride and serum HDL were independently associated with the presence of obesity.

CONCLUSIONS:

The observed genotype distributions revealed a significant association of PC-1 K121Q with obesity. PC-1 Q121 carriers are more likely to be insulin-resistant or get fatter in respect to KK subjects and carriers of the Q allele are at higher risk for the development of obesity in female.

• Authors: C Wan, T Zhang, B Wang, Y Han, C Zhang, Y Zhang, H Gong, F Jin, L Wang
• Journal: Diabetes, obesity & metabolism (Diabetes Obes Metab) Vol. 8 Issue 6 Pg. 703-8 (Nov 2006) ISSN: 1462-8902 [Print] England
• PMID: 17026496 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Lipids
• Phosphoric Diester Hydrolases
• ectonucleotide pyrophosphatase phosphodiesterase 1
• Pyrophosphatases

Topics

• Adult
• Aged
• Body Mass Index
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Genotype
• Humans
• Insulin Resistance (genetics)
• Lipids (blood)
• Male
• Middle Aged
• Obesity (blood, genetics)
• Phenotype
• Phosphoric Diester Hydrolases (genetics)
• Polymorphism, Genetic
• Polymorphism, Restriction Fragment Length
• Pyrophosphatases (genetics)