[The role of gap junction communication in metastatic B16 melanoma in C57BL mice].

Abstract

The study is concerned with the effects of non-specific blocking gap junction communication with oleamide as well as genesis and spreading of melanoma B16 metastases to the lung in mice C57B1. The blocking exerted no distinct influence on primary tumorigenesis but had a marked effect on metastatic spread. Oleamide treatment during tumor growth led to an increase in area covered by metastases. A correlation was established between metastatic frequency and dosage: 1 mg/kg was followed by an upsurge in frequency of secondary lung tumors while 10 mg/kg--by a drop.

• Authors: E S Fëdorov, G M Manikhas, N N Petrishchëv, M V Dubina
• Journal: Voprosy onkologii (Vopr Onkol) Vol. 52 Issue 4 Pg. 433-7 ( 2006) ISSN: 0507-3758 [Print] Russia (Federation)
• PMID: 17024817 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents
• Carcinogens
• Oleic Acids
• oleylamide

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Carcinogens
• Cell Communication
• Disease Progression
• Gap Junctions
• Humans
• Male
• Melanoma, Experimental (physiopathology, ultrastructure)
• Mice
• Mice, Inbred C57BL
• Oleic Acids (adverse effects, pharmacology)